Article
Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.
Annals of the rheumatic diseases - 1 Jul 2013
Diaz-Gallo Lina-Marcela, Simeon Carmen P, Broen Jasper C, Ortego-Centeno Norberto, Beretta Lorenzo, Vonk Madelon C, Carreira Patricia E, Vargas Sofia, Román-Ivorra José Andrés, González-Gay Miguel A, Tolosa Carlos, López-Longo Francisco Javier, Espinosa Gerard, Vicente Esther F, Hesselstrand Roger, Riemekasten Gabriela, Witte Torsten, Distler Jörg H W, Voskuyl Alexandre E, Schuerwegh Annemie J, Shiels Paul G, Nordin Annika, Padyukov Leonid, Hoffmann-Vold Anna-Maria, Scorza Raffaella, Lunardi Claudio, Airo Paolo, van Laar Jacob M, Hunzelmann Nicolas, Gathof Birgit S, Kreuter Alexander, Herrick Ariane, Worthington Jane, Denton Christopher P, Zhou Xiaodong, Arnett Frank C, Fonseca Carmen, Koeleman Bobby P C, Assasi Shervin, Radstake Timothy R D J, Mayes Maureen D, Martín Javier
Abstract excerpt
OBJECTIVE: The interleukin 2 (IL-2) and interleukin 21 (IL-21) locus at chromosome 4q27 has been associated with several autoimmune diseases, and both genes are related to immune system functions. The aim of this study was to evaluate the role of the IL-2/IL-21 locus in systemic sclerosis (SSc). PATIENTS AND METHODS: The case control study included 4493 SSc Caucasian patients and 5856 healthy controls from eight...
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