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Article

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Apr 2008

Sawalha A H, Kaufman K M, Kelly J A, Adler A J, Aberle T, Kilpatrick J, Wakeland E K, Li Q-Z, Wandstrat A E, Karp D R, James J A, Merrill J T, Lipsky P, Harley J B

Abstract excerpt

OBJECTIVE: The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of the disease. Herein, we describe genetic association between SLE and polymorphisms in the interleukin (IL)-21 gene. The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell...

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Identifiers

PMID: 17720724
DOI: 10.1136/ard.2007.075424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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