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Article

The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus.

Gene - 15 Mar 2014

Lan Yan, Luo Bin, Wang Jun-Li, Jiang Yuan-Wen, Wei Ye-Sheng

Abstract excerpt

Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. Previous studies have identified that IL-21 was associated with...

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PMID: 24434811
DOI: 10.1016/j.gene.2014.01.012

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