Multiple genes, especially immune-regulating genes, contribute to disease susceptibility in systemic sclerosis.

doi:10.1097/BOR.0000000000000334

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Article

Multiple genes, especially immune-regulating genes, contribute to disease susceptibility in systemic sclerosis.

Current opinion in rheumatology - 1 Nov 2016

Ma Yunqing, Zhou Xiaodong

Abstract excerpt

PURPOSE OF REVIEW: Systemic sclerosis (SSc) is a complex autoimmune disorder that occurs in a genetically susceptible host. Genetic studies of SSc in recent years have defined or suggested a number of new genes with polymorphisms conferring susceptibility to or protection against SSc. RECENT FINDINGS: Although not all genes fall neatly into one functional category, the major genes with polymorphisms associated...

Topics

Autoimmune Diseases
Genetic Predisposition to Disease
Humans
Immunity, Innate
Polymorphism, Genetic
Scleroderma, Systemic
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 27533323
DOI: 10.1097/BOR.0000000000000334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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