Influence of the IL6 gene in susceptibility to systemic sclerosis.

doi:10.3899/jrheum.120506

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Article

Influence of the IL6 gene in susceptibility to systemic sclerosis.

The Journal of rheumatology - 1 Dec 2012

Cénit Maria Carmen, Simeón Carmen P, Vonk Madelon C, Callejas-Rubio Jose L, Espinosa Gerard, Carreira Patricia, Blanco Francisco J, Narvaez Javier, Tolosa Carlos, Román-Ivorra José A, Gómez-García Inmaculada, García-Hernández Francisco J, Gallego María, García-Portales Rosa, Egurbide María Victoria, Fonollosa Vicente, García de la Peña Paloma, López-Longo Francisco J, González-Gay Miguel A, Hesselstrand Roger, Riemekasten Gabriela, Witte Torsten, Voskuyl Alexandre E, Schuerwegh Annemie J, Madhok Rajan, Fonseca Carmen, Denton Christopher, Nordin Annika, Palm Øyvind, van Laar Jacob M, Hunzelmann Nicolas, Distler Jörg H W, Kreuter Alexander, Herrick Ariane, Worthington Jane, Koeleman Bobby P, Radstake Timothy R D J, Martín Javier

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) is a genetically complex autoimmune disease; the genetic component has not been fully defined. Interleukin 6 (IL-6) plays a crucial role in immunity and fibrosis, both key aspects of SSc. We investigated the influence of IL6 gene in the susceptibility and phenotype expression of SSc. METHODS: We performed a large metaanalysis including a total of 2749 cases and 3189 controls...

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Identifiers

PMID: 23027890
DOI: 10.3899/jrheum.120506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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