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Article

Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.

European journal of human genetics : EJHG - 1 Jul 2010

Cavanillas María L, Alcina Antonio, Núñez Concepción, de las Heras Virginia, Fernández-Arquero Miguel, Bartolomé Manuel, de la Concha Emilio G, Fernández Oscar, Arroyo Rafael, Matesanz Fuencisla, Urcelay Elena

Abstract excerpt

Interleukin (IL)-2/IL-2R signalling promotes proliferation and survival of activated T cells and has an essential non-redundant role in the production of regulatory T cells. Associations with different autoimmune diseases of polymorphisms in a linkage disequilibrium block in which the IL2/IL21 genes map (4q27), and also in genes encoding the IL2RA and IL2RB subunits (located in 10p15 and 22q13, respectively),...

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Identifiers

PMID: 20179739
DOI: 10.1038/ejhg.2010.15
PMCID: PMC2987360

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