Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.

doi:10.1002/art.30320

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Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.

Arthritis and rheumatism - 1 Jun 2011

Hughes Travis, Kim-Howard Xana, Kelly Jennifer A, Kaufman Kenneth M, Langefeld Carl D, Ziegler Julie, Sanchez Elena, Kimberly Robert P, Edberg Jeffrey C, Ramsey-Goldman Rosalind, Petri Michelle, Reveille John D, Martín Javier, Brown Elizabeth E, Vilá Luis M, Alarcón Graciela S, James Judith A, Gilkeson Gary S, Moser Kathy L, Gaffney Patrick M, Merrill Joan T, Vyse Timothy J, Alarcón-Riquelme Marta E, Nath Swapan K, Harley John B, Sawalha Amr H

Abstract excerpt

OBJECTIVE: Genetic association of the IL2/IL21 region at chromosome 4q27 has previously been reported in lupus and a number of autoimmune and inflammatory diseases. This study was undertaken to determine whether this genetic effect could be localized, using a very large cohort of lupus patients and controls. METHODS: We genotyped 45 tag single-nucleotide polymorphisms (SNPs) across the IL2/IL21 locus in 2 large...

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PMID: 21425124
DOI: 10.1002/art.30320
PMCID: PMC3106139

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