Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder.

doi:10.1097/WNR.0000000000001528

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Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder.

Neuroreport - 4 Nov 2020

Shen Zonglin, Lu Yi, Jiang Hongyan, Ye Jing, Zhou Cong, He Mengxin, Li Na, Xu Xiufeng, Cheng Yuqi

Abstract excerpt

OBJECTIVE: The neuro-anatomical substrates of major depressive disorder (MDD) remain poorly understood. Brain-derived neurotrophic factor (BDNF) gene polymorphism (Val66Met/rs6265) is associated with neuro-plasticity and development. In the present study, we explore the influence of BDNF gene polymorphism on cortical thickness in nonelderly, first episode, drug-naive patients with MDD. METHODS: Two hundred and...

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PMID: 32991522
DOI: 10.1097/WNR.0000000000001528

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