Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.

The British journal of psychiatry : the journal of mental science - 1 May 2015

Legge Rebecca MacGregor, Sendi Shahbaz, Cole James H, Cohen-Woods Sarah, Costafreda Sergi G, Simmons Andrew, Farmer Anne E, Aitchison Katherine J, McGuffin Peter, Fu Cynthia H Y

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD. AIMS: To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions. METHOD:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain-Derived Neurotrophic Factor

Share to Case-Control Studies

Share to Depressive Disorder, Major

Share to Genetic Predisposition to Disease

Share to Magnetic Resonance Imaging

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 25745134
DOI: 10.1192/bjp.bp.113.143529
PMCID: PMC4416135

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.PMID 25745134Read ↗

Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder.Semantic proximity Read ↗

Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI.Semantic proximity Read ↗

The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.Semantic proximity Read ↗

Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.Semantic proximity Read ↗

The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.Semantic proximity Read ↗

Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.Semantic proximity Read ↗

Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.Semantic proximity Read ↗

Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia.Semantic proximity Read ↗

Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.Semantic proximity Read ↗

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis.Semantic proximity Read ↗

A Meta-Analysis of Brain-Derived Neurotrophic Factor Effects on Brain Volume in Schizophrenia: Genotype and Serum Levels.Semantic proximity Read ↗

Association of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: An exploratory study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.