Article
Genetic characterization of preschool wheeze phenotypes.
The Journal of allergy and clinical immunology - 1 Dec 2025
Fischer-Rasmussen Kasper, Granell Raquel, Eliasen Anders Ulrik, Kreiner Eskil, Pedersen Casper-Emil Tingskov, Luo Yang, Chawes Bo, Stokholm Jakob, Malby Schoos Ann-Marie, Kumar Ashish, Nybo Andersen Anne-Marie, Feenstra Bjarke, Geller Frank, Siroux Valérie, Demenais Florence, Bouzigon Emmanuelle, Jaddoe Vincent, van der Valk Ralf J P, Duijts Liesbeth, Sunyer Jordi, Guxens Mónica, Marinelli Marcella, Bustamante Mariona, Heinrich Joachim, Standl Marie, Curtin John, Simpson Angela, Murray Clare, Jacobsson Bo, Myhre Ronny, Pennell Craig E, Daley Denise, Ober Carole, Gern James E, Jackson Daniel, Boomsma Dorret I, Hottenga Jouke-Jan, Abdellaoui Abdel, Holloway John W, Collins Sam, Turner Stephen, Arshad S Hasan, Ullah Anhar, Melén Erik, Henderson John, Bisgaard Hans, Pedersen Anders Gorm, Custovic Adnan, Vonk Judith M, Koppelman Gerard H, Kabesch Michael, Bønnelykke Klaus
Abstract excerpt
BACKGROUND: Preschool wheeze is a heterogenous and poorly understood clinical syndrome. As a result, current treatments are insufficient, and prevention is not possible. OBJECTIVE: We sought to increase understanding of the genetic susceptibility and underlying disease mechanisms of wheeze phenotypes in early childhood through large-scale genome-wide association study analyses. METHODS: We performed meta-analyses...
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