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Article

Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort.

The Journal of allergy and clinical immunology - 1 Aug 2012

Spycher Ben D, Henderson John, Granell Raquel, Evans David M, Smith George Davey, Timpson Nicholas J, Sterne Jonathan A C

Abstract excerpt

BACKGROUND: Childhood wheezing and asthma vary greatly in clinical presentation and time course. The extent to which phenotypic variation reflects heterogeneity in disease pathways is unclear. OBJECTIVE: We sought to assess the extent to which single nucleotide polymorphisms (SNPs) associated with childhood asthma in a genome-wide association study are predictive of asthma-related phenotypes. METHODS: In 8365...

Topics

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Asthma
Bronchial Hyperreactivity
Hypersensitivity, Immediate
Longitudinal Studies
Predictive Value of Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory Function Tests

Respiratory Sounds

Severity of Illness Index

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Open in PubMed Open full text

Identifiers

PMID: 22846752
DOI: 10.1016/j.jaci.2012.06.002
PMCID: PMC4871225

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