Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment.

PloS one - 1 Jan 2012

Muthu Raja Karthick Raja, Kubiczkova Lenka, Rihova Lucie, Piskacek Martin, Vsianska Pavla, Hezova Renata, Pour Ludek, Hajek Roman

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aimed to prove the presence of functionally suppressive Treg cells expressing CD8 phenotype (CD8 Treg cells) in MM. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Electrophoresis, Agar Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Interferon-gamma

Share to Interleukin-2 Receptor alpha Subunit

Share to Lymphocyte Count

Share to Multiple Myeloma

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 23152910
DOI: 10.1371/journal.pone.0049446
PMCID: PMC3496705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment.PMID 23152910Read ↗

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state.Semantic proximity Read ↗

The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status.Semantic proximity Read ↗

Mass Cytometry Discovers Two Discrete Subsets of CD39−Treg Which Discriminate MGUS From Multiple MyelomaSemantic proximity Read ↗

Functional Role of Granulocytic Myeloid-Derived Suppressor Cells in CAR-T Therapy: Insights from Single- Cell RNA Sequencing in Multiple MyelomaSemantic proximity Read ↗

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma.Semantic proximity Read ↗

Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent.Semantic proximity Read ↗

Treg-derived TGF-β1 dampens cGAS-STING signaling to downregulate the expression of class I MHC complex in multiple myelomaSemantic proximity Read ↗

Increased exhausted CD8+ T cells with programmed death-1, T-cell immunoglobulin and mucin-domain-containing-3 phenotype in patients with multiple myeloma.Semantic proximity Read ↗

CD4+ T Cell Dependent B Cell Recovery and Function After Autologous Hematopoietic Stem Cell Transplantation.Semantic proximity Read ↗

IL-10R Inhibition Reprograms Tumor-Associated Macrophages and Reverses Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

Treatment with lenalidomide induces immunoactivating and counter-regulatory immunosuppressive changes in myeloma patients.Semantic proximity Read ↗

Expansion of immunoglobulin autoreactive T-helper cells in multiple myeloma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.