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Functional Role of Granulocytic Myeloid-Derived Suppressor Cells in CAR-T Therapy: Insights from Single- Cell RNA Sequencing in Multiple Myeloma

2025-05-07

Abstract excerpt

<title>Abstract</title> <p>Immunotherapies, including chimeric antigen receptor T-cell (CAR-T) therapy, represent a pivotal approach in the treatment of multiple myeloma (MM). However, the complex immunosuppressive tumor microenvironment (TME) poses significant challenges to their efficacy. Among the immunosuppressive cells in the MM TME, granulocytic myeloid-derived suppressor cells (G-MDSCs) are predominant; ho...

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Literature Corpus work
f8dd2eed-ee38-50b5-bf3f-c749e1159597
DOI
10.21203/rs.3.rs-6437282/v1
Open publication

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