Article
Increased exhausted CD8+ T cells with programmed death-1, T-cell immunoglobulin and mucin-domain-containing-3 phenotype in patients with multiple myeloma.
Asia-Pacific journal of clinical oncology - 1 Oct 2018
Tan Jiaxiong, Chen Shaohua, Huang Jingying, Chen Youchun, Yang Lijian, Wang Chunli, Zhong Jun, Lu Yuhong, Wang Liang, Zhu Kanger, Li Yangqiu
Abstract excerpt
AIM: The immunosuppressive microenvironment plays a crucial role in T-cell immunodeficiency in multiple myeloma (MM). Overexpression of T-cell immunosuppressive receptors, including programmed death-1 (PD-1) and T-cell immunoglobulin and mucin-domain-containing-3 (Tim-3), may be related to tumor immunosuppression and poor prognosis, and the malignant bone marrow (BM) microenvironment may contribute to such...
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