Article
Expansion of immunoglobulin autoreactive T-helper cells in multiple myeloma.
Blood - 1 Mar 2008
Ostad Masih, Andersson Margareta, Gruber Astrid, Sundblad Anne
Abstract excerpt
Activation and expansion of T helper (Th) cells followed by regulation of activation are essential to the generation of immune responses while limiting concomitant autoreactivity. In order to characterize T cells reactive towards myeloma-derived monoclonal immunoglobulin (mIg), an autologous coculture assay for single-cell analysis of mIg-responding cells was developed. When cultured with dendritic cells loaded...
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