Article

IL-10R Inhibition Reprograms Tumor-Associated Macrophages and Reverses Drug Resistance in Multiple Myeloma

2022-09-27

Abstract excerpt

<title>Abstract</title> <p>Multiple myeloma (MM) is the cancer of plasma cells within the bone marrow (BM) and remains incurable. Tumor-associated macrophages (TAMs) within the tumor microenvironment often display a pro-tumor phenotype and correlate with tumor proliferation, survival, and therapy resistance. Thus, TAMs have become an emerging target of interest. IL-10 is a key immunosuppressive cytokine that lead...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ef60961-69e4-53ab-aacf-608e466c06d3
DOI: 10.21203/rs.3.rs-2073669/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IL-10R Inhibition Reprograms Tumor-Associated Macrophages and Reverses Drug Resistance in Multiple MyelomaDOI 10.21203/rs.3.rs-2073669/v1Read

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype.Semantic proximity Read

Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myelomaSemantic proximity Read

Targeting NF-κB Signaling for Multiple MyelomaSemantic proximity Read

Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug ResistanceSemantic proximity Read

Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Semantic proximity Read

Molecular and immunological mechanisms of clonal evolution in multiple myelomaSemantic proximity Read

Elevated levels of Protein S in Multiple Myeloma bone marrow microenvironment regulate tumor progression and bone diseaseSemantic proximity Read

A gene expression inflammatory signature specifically predicts multiple myeloma evolution and patients survivalSemantic proximity Read

A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stagesSemantic proximity Read

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYCSemantic proximity Read

IL-17/miR-192/IL-17Rs Regulatory Feedback Loop Facilitates Multiple Myeloma ProgressionSemantic proximity Read

How to Reprogram Myeloma-Associated Macrophages: Target IKZF1.Semantic proximity Read