Article
The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status.
Haematologica - 1 Oct 2014
Foglietta Myriam, Castella Barbara, Mariani Sara, Coscia Marta, Godio Laura, Ferracini Riccardo, Ruggeri Marina, Muccio Vittorio, Omedé Paola, Palumbo Antonio, Boccadoro Mario, Massaia Massimo
Abstract excerpt
Conflicting data have been reported about the frequency and function of regulatory T cells in multiple myeloma. Most studies have investigated peripheral blood rather than bone marrow Tregs and side-by-side comparisons with bone marrow from healthy donors have still not been made. In this study, we show that regulatory T-cells total count, subset distribution, and expression of chemokine receptors are similar in...
Topics
- Biopsy
- Bone Marrow
- Case-Control Studies
- Humans
- Immunomodulation
- Immunophenotyping
- Lymphocyte Count
- Monoclonal Gammopathy of Undetermined Significance
- Multiple Myeloma
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocytes, Regulatory