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Article

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.

The Journal of biological chemistry - 4 Jan 2013

Barbolina Maria V, Liu Yiuying, Gurler Hilal, Kim Mijung, Kajdacsy-Balla Andre A, Rooper Lisa, Shepard Jaclyn, Weiss Michael, Shea Lonnie D, Penzes Peter, Ravosa Matthew J, Stack M Sharon

Abstract excerpt

Cells respond to changes in the physical properties of the extracellular matrix with altered behavior and gene expression, highlighting the important role of the microenvironment in the regulation of cell function. In the current study, culture of epithelial ovarian cancer cells on three-dimensional collagen I gels led to a dramatic down-regulation of the Wnt signaling inhibitor dickkopf-1 with a concomitant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23152495
DOI: 10.1074/jbc.M112.431411
PMCID: PMC3537008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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