Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β <sub>1</sub> Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

11 Feb 2014

Abstract excerpt

Interactions with the extracellular matrix (ECM) through integrin adhesion receptors provide cancer cells with physical and chemical cues that act together with growth factors to support survival and proliferation. Antagonists that target integrins containing the β1 subunit inhibit tumor growth and sensitize cells to irradiation or cytotoxic chemotherapy in preclinical breast cancer models and are under clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Cell Adhesion Molecules Research
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24518294
DOI: 10.1126/scisignal.2004751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β <sub>1</sub> Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast CancerPMID 24518294Read ↗

Integrin signaling in tumor biology: mechanisms of intercellular crosstalk and emerging targeted therapiesSemantic proximity Read ↗

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-βSemantic proximity Read ↗

Beyond adhesion: emerging roles for integrins in control of the tumor microenvironmentSemantic proximity Read ↗

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKLSemantic proximity Read ↗

Kindlin-2 Regulates the Oncogenic Activities of Integrins and TGF-β In Triple Negative Breast Cancer Progression and MetastasisSemantic proximity Read ↗

Integrins and cancer.Semantic proximity Read ↗

Kindlin-2 regulates the oncogenic activities of integrins and TGF-β in triple-negative breast cancer progression and metastasisSemantic proximity Read ↗

Integrins Within the Tumor Microenvironment: Biological Functions and Advances in Therapeutic Targeting <strong> </strong>Semantic proximity Read ↗

Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

The complexity of integrins in cancer and new scopes for therapeutic targetingSemantic proximity Read ↗

Role of c-Met/β1 integrin complex in the metastatic cascadeSemantic proximity Read ↗

LRP-1 promotes tumor progression of triple negative breast cancers by coordinating extracellular matrix remodeling and immune cell infiltrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.