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Article

Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.

PloS one - 19 Apr 2011

Kwon Youngjoo, Cukierman Edna, Godwin Andrew K

Abstract excerpt

Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model and time-lapse and confocal imaging. Twelve ovarian tumor cells were evaluated and classified into distinct groups...

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Identifiers

PMID: 21526198
DOI: 10.1371/journal.pone.0018872
PMCID: PMC3079735

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Source receipt: pubmed, retrieved 7 Sept 2026.

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