Article
Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype.
Investigative ophthalmology & visual science - 3 Jun 2020
Dhamodaran Kamesh, Baidouri Hasna, Sandoval Lyndsey, Raghunathan VijayKrishna
Abstract excerpt
Purpose: Wnt is a spatiotemporally regulated signaling pathway whose inhibition is associated with glaucoma, elevated intraocular pressure (IOP), and cell stiffening. Whether such changes are permanent or may be reversed is unclear. Here, we determine if activation of Wnt pathway after inhibition reverses the pathologic phenotype. Methods: Primary human trabecular meshwork (hTM) cells from nonglaucomatous donors...
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