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Article

Regulation of cancer invasiveness by the physical extracellular matrix environment

1 Jul 2009

Abstract excerpt

Long-term clinical outcomes are dependent on whether carcinoma cells leave the primary tumor site and invade through adjacent tissue. Recent evidence links tissue rigidity to alterations in cancer cell phenotype and tumor progression. We found that rigid extracellular matrix (ECM) substrates promote invasiveness of tumor cells via increased activity of invadopodia, subcellular protrusions with associated...

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Identifiers

PMID: 19458499
DOI: 10.4161/cam.3.3.8888

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