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Article

Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids.

Reproduction (Cambridge, England) - 1 Jan 2018

Ko Yi-An, Jamaluddin M Fairuz B, Adebayo Mariam, Bajwa Preety, Scott Rodney J, Dharmarajan Arunasalam M, Nahar Pravin, Tanwar Pradeep S

Abstract excerpt

Recent studies showed that genetic aberrations in the MED12 gene, probably through the canonical WNT/β-catenin pathway, lead to the pathogenesis of uterine fibroids. However, a comprehensive analysis of the WNT pathway in MED12-mutated and MED12-wild-type fibroids has not been performed. The objective of this study was to determine the status of the WNT pathway in human fibroids. We performed Sanger sequencing to...

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Source

Identifiers

PMID: 29066531
DOI: 10.1530/REP-17-0339

Genes

MED12
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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