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Article

Increased extracellular matrix density disrupts E-cadherin/β-catenin complex in gastric cancer cells

1 Jan 2018

Abstract excerpt

During gastric cancer (GC) progression, increased extracellular matrix (ECM) deposition, notably collagen type I, correlates with an overall increase in expression of the mesenchymal phenotype. In GC tissue, the intestinal epithelium exhibits impaired cell-cell adhesion and enhanced cell-ECM adhesion. The alteration of intercellular integrity is one of tumorigenesis feature including tumor invasion and...

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PMID: 30151505
DOI: 10.1039/c8bm00843d

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