Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency.

The Journal of allergy and clinical immunology - 1 Jun 2024

Huang Xubo, Huang Jinxia, Li Xiumei, Fan Jingxian, Zhou Desheng, Qu Hui-Qi, Glessner Joseph T, Ji Dandan, Jia Qi, Ding Zhiyong, Wang Nan, Wei Wei, Lyu Xing, Li Mulin Jun, Liu Zhe, Liu Wei, Wei Yongjie, Hakonarson Hakon, Xia Qianghua, Li Jin

Abstract excerpt

BACKGROUND: CLEC16A intron 19 has been identified as a candidate locus for common variable immunodeficiency (CVID). OBJECTIVES: This study sought to elucidate the molecular mechanism by which variants at the CLEC16A intronic locus may contribute to the pathogenesis of CVID. METHODS: The investigators performed fine-mapping of the CLEC16A locus in a CVID cohort, then deleted the candidate functional SNP in T-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Common Variable Immunodeficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Introns

Share to Lectins, C-Type

Share to Monosaccharide Transport Proteins

Share to Polymorphism, Single Nucleotide

Share to Signal Transduction

Source

Identifiers

PMID: 38191060
DOI: 10.1016/j.jaci.2023.12.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency.PMID 38191060Read ↗

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.Semantic proximity Read ↗

Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus SusceptibilitySemantic proximity Read ↗

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.Semantic proximity Read ↗

DOCK8 deficiency due to a deep intronic variant in two kindreds with hyper-IgE syndrome.Semantic proximity Read ↗

CLEC16A—An Emerging Master Regulator of Autoimmunity and NeurodegenerationSemantic proximity Read ↗

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.Semantic proximity Read ↗

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.Semantic proximity Read ↗

<i>UBA1-CDK16</i> : A Sex-Specific Chimeric RNA and Its Role in Immune Sexual DimorphismSemantic proximity Read ↗

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16ASemantic proximity Read ↗

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.Semantic proximity Read ↗

Narrowing the FOXF1 distant enhancer region on 16q24.1 critical for ACDMPVSemantic proximity Read ↗

Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.