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Article

B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.

Scientific reports - 9 Mar 2017

Chou Wen-Cheng, Chen Wei-Ting, Hsiung Chia-Ni, Hu Ling-Yueh, Yu Jyh-Cherng, Hsu Huan-Ming, Shen Chen-Yang

Abstract excerpt

The key signature of cancer genomes is the accumulation of DNA mutations, the most abundant of which is the cytosine-to-thymine (C-to-T) transition that results from cytosine deamination. Analysis of The Cancer Genome Atlas (TCGA) database has demonstrated that this transition is caused mainly by upregulation of the cytosine deaminase APOBEC3B (A3B), but the mechanism has not been completely characterized. We...

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Identifiers

PMID: 28276478
DOI: 10.1038/srep44089
PMCID: PMC5343453

Genes

EGF
MYBL2

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