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Article

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005

Yoon Byeong S, Ovchinnikov Dmitry A, Yoshii Isaac, Mishina Yuji, Behringer Richard R, Lyons Karen M

Abstract excerpt

Previous studies have demonstrated the ability of bone morphogenetic proteins (BMPs) to promote chondrogenic differentiation in vitro. However, the in vivo role of BMP signaling during chondrogenesis has been unclear. We report here that BMP signaling is essential for multiple aspects of early chondrogenesis. Whereas mice deficient in type 1 receptors Bmpr1a or Bmpr1b in cartilage are able to form intact...

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Identifiers

PMID: 15781876
DOI: 10.1073/pnas.0500031102
PMCID: PMC555995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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