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Article

Opposing roles of pRB and p107 in adipocyte differentiation

19 Sept 2000

Abstract excerpt

The retinoblastoma (RB) family of proteins, pRB, p107, and p130, have been postulated to be partially redundant in their ability to regulate progression through the G(1) phase of the cell cycle. However, pRB appears to be unique in its capacity as a classical tumor suppressor, possibly because of a specialized role in maintaining the balance between proliferation and differentiation. A variety of studies have in...

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Identifiers

PMID: 10995476
DOI: 10.1073/pnas.190343597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Opposing roles of pRB and p107 in adipocyte differentiationPMID 10995476Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1αSemantic proximity Read ↗

Role of the Retinoblastoma Protein in Differentiation and SenescenceSemantic proximity Read ↗

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.Semantic proximity Read ↗

The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic TransformationSemantic proximity Read ↗

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.Semantic proximity Read ↗

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.Semantic proximity Read ↗

Rb family proteins differentially regulate distinct cell lineages during epithelial development.Semantic proximity Read ↗

Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells <i>In vivo</i> Critical for Suppressing Cell Growth and TumorigenesisSemantic proximity Read ↗

Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiationSemantic proximity Read ↗

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.Semantic proximity Read ↗

G1 arrest and differentiation can occur independently of Rb family functionSemantic proximity Read ↗

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