Article
Avapritinib in the treatment of PDGFRA exon 18 mutated gastrointestinal stromal tumors.
Future oncology (London, England) - 1 Aug 2020
Smrke Alannah, Gennatas Spyridon, Huang Paul, Jones Robin L
Abstract excerpt
Gastrointestinal stromal tumors (GIST) can be molecularly classified based on different subtypes including mutations in KIT and PDGFRA. Patients with PDGFRA mutations are an important subgroup that commonly arise in the stomach and are associated with a more indolent disease course. Importantly, the most common PDGFRA molecular subtype, the D842V mutation in exon 18 of the gene which alters the activation loop,...
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