Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

Cancer - 1 Jun 2015

Stremitzer Stefan, Zhang Wu, Yang Dongyun, Ning Yan, Stintzing Sebastian, Sebio Ana, Sunakawa Yu, Yamauchi Shinichi, Matsusaka Satoshi, El-Khoueiry Rita, Stift Judith, Wrba Friedrich, Gruenberger Thomas, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases who undergo liver resection and receive perioperative, bevacizumab-based chemotherapy. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Angiopoietins

Share to Colorectal Neoplasms

Share to Disease-Free Survival

Share to Genetic Variation

Share to Liver Neoplasms

Share to Pericytes

Source

Open in PubMed Open full text

Identifiers

PMID: 25690670
DOI: 10.1002/cncr.29259
PMCID: PMC4441595

Genes

RALBP1
PDGFB
ANGPT2
TEK
ANGPT1
IGF1
PDGFRB
RGS5
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.PMID 25690670Read ↗

Clinical implications of genetic variations in the VEGF system in relation to colorectal cancer.Semantic proximity Read ↗

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome.Semantic proximity Read ↗

Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection.Semantic proximity Read ↗

Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients.Semantic proximity Read ↗

Genetic variation in the transforming growth factor-β signaling pathway and survival after diagnosis with colon and rectal cancer.Semantic proximity Read ↗

Differential expression of angiogenesis-related genes ‘VEGF’ and ‘angiopoietin-1’ in metastatic and EMAST-positive colorectal cancer patientsSemantic proximity Read ↗

Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy.Semantic proximity Read ↗

Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.Semantic proximity Read ↗

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical ResectionSemantic proximity Read ↗

Single-nucleotide polymorphisms in the vascular endothelial growth factor pathway and outcomes of patients treated with first-line cytotoxic chemotherapy combined with bevacizumab for advanced colorectal cancer.Semantic proximity Read ↗

Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors.Semantic proximity Read ↗

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.