Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression.

Breast cancer research : BCR - 1 Jan 2005

Carvalho Inês, Milanezi Fernanda, Martins Albino, Reis Rui M, Schmitt Fernando

Abstract excerpt

INTRODUCTION: Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers. Platelet-derived growth factor receptors (PDGFRs) are receptors with intrinsic tyrosine kinase activity that regulate several functions in normal cells and are widely expressed in a variety of malignancies. After the demonstration that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Intraductal, Noninfiltrating
Share to Gastrointestinal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Carrier Screening

Share to Introns

Share to Neoplasm Invasiveness

Share to Polymorphism, Single-Stranded Conformational

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 16168125
DOI: 10.1186/bcr1304
PMCID: PMC1242156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression.PMID 16168125Read ↗

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesSemantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Oncogenic derivatives of platelet-derived growth factor receptors.Semantic proximity Read ↗

Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.Semantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

Platelet-derived growth factor receptor alpha in glioma: a bad seedSemantic proximity Read ↗

Characterization and Targeting of Platelet-Derived Growth Factor Receptor alpha (PDGFRA) in Inflammatory Breast Cancer (IBC).Semantic proximity Read ↗

Functional and clinical roles of stromal PDGF receptors in tumor biologySemantic proximity Read ↗

PDGF receptors as targets in tumor treatment.Semantic proximity Read ↗

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway.Semantic proximity Read ↗

Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size.Semantic proximity Read ↗

PDGF receptors as cancer drug targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.