Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

8 Nov 2012

Abstract excerpt

Secretory polymorphic serine/threonine kinases control pathogenesis of Toxoplasma gondii in the mouse. Genetic studies show that the pseudokinase ROP5 is essential for acute virulence, but do not reveal its mechanism of action. Here we demonstrate that ROP5 controls virulence by blocking IFN-γ mediated clearance in activated macrophages. ROP5 was required for the catalytic activity of the active S/T kinase ROP18,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Mosquito-borne diseases and control
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23144612
DOI: 10.1371/journal.ppat.1002992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18PMID 23144612Read ↗

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.Semantic proximity Read ↗

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance ProteinsSemantic proximity Read ↗

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulenceSemantic proximity Read ↗

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondiiSemantic proximity Read ↗

ATF6β is a host cellular target of the <i>Toxoplasma gondii</i> virulence factor ROP18Semantic proximity Read ↗

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence.Semantic proximity Read ↗

A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.Semantic proximity Read ↗

The Toxoplasma Pseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPasesSemantic proximity Read ↗

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondiiSemantic proximity Read ↗

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceSemantic proximity Read ↗

The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell deathSemantic proximity Read ↗

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.