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A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

10 Jul 2012

Abstract excerpt

The ability of mice to resist infection with the protozoan parasite, Toxoplasma gondii, depends in large part on the function of members of a complex family of atypical large GTPases, the interferon-gamma-inducible immunity-related GTPases (IRG proteins). Nevertheless, some strains of T. gondii are highly virulent for mice because, as recently shown, they secrete a polymorphic protein kinase, ROP18, from the...

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PMID: 22802726
DOI: 10.1371/journal.pbio.1001358

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Related research

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A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance ProteinsPMID 22802726Read ↗

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The Toxoplasma Pseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPasesSemantic proximity Read ↗

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ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulenceSemantic proximity Read ↗

The<i>Toxoplasma gondii</i>rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7Semantic proximity Read ↗

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The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondiiSemantic proximity Read ↗

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondiiSemantic proximity Read ↗

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondiiSemantic proximity Read ↗

ATF6β is a host cellular target of the <i>Toxoplasma gondii</i> virulence factor ROP18Semantic proximity Read ↗

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceSemantic proximity Read ↗

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