Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondii

20 Aug 2012

Abstract excerpt

Toxoplasma gondii uses specialized secretory organelles called rhoptries to deliver virulence determinants into the host cell during parasite invasion. One such determinant called rhoptry protein 18 (ROP18) is a polymorphic serine/threonine kinase that phosphorylates host targets to modulate acute virulence. Following secretion into the host cell, ROP18 traffics to the parasitophorous vacuole membrane (PVM) where...

Topics

Join the communities discussing this publication.

Mosquito-borne diseases and control
Parasitic Infections and Diagnostics
Toxoplasma gondii Research Studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22906355
DOI: 10.1111/cmi.12022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondiiPMID 22906355Read ↗

ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondiiSemantic proximity Read ↗

The<i>Toxoplasma gondii</i>rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7Semantic proximity Read ↗

ATF6β is a host cellular target of the <i>Toxoplasma gondii</i> virulence factor ROP18Semantic proximity Read ↗

Translocation of dense granule effectors across the parasitophorous vacuole membrane in <i>Toxoplasma</i> -infected cells requires the activity of ROP17, a rhoptry protein kinaseSemantic proximity Read ↗

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.Semantic proximity Read ↗

Toxoplasma gondii rhoptry protein38 (TgROP38) affects parasite invasion, egress, and induces IL-18 secretion during early infection.Semantic proximity Read ↗

A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.Semantic proximity Read ↗

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18Semantic proximity Read ↗

Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membraneSemantic proximity Read ↗

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma- Infected Cells Requires the Activity of ROP17, a Rhoptry Protein KinaseSemantic proximity Read ↗

Interactions between the ROP18 kinase and host cell proteins that aid in the parasitism of Toxoplasma gondiiSemantic proximity Read ↗

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.