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Article

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Alaganan Aditi, Fentress Sarah J, Tang Keliang, Wang Qiuling, Sibley L David

Abstract excerpt

The intracellular parasite Toxoplasma gondii enjoys a wide host range and is adept at surviving in both naive and activated macrophages. Previous studies have emphasized the importance of the active serine-threonine protein kinase rhoptry protein 18 (ROP18), which targets immunity-related GTPases (IRGs), in mediating macrophage survival and acute virulence of T. gondii in mice. Here, we demonstrate that ROP18...

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Identifiers

PMID: 24390541
DOI: 10.1073/pnas.1313501111
PMCID: PMC3903209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.PMID 24390541Read ↗

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