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The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death

15 Jan 2025

Abstract excerpt

Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death and the effectors involved remain poorly characterized. We identified ROP55, a rhoptry protein that promotes parasite survival by preventing lytic cell death in...

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PMID: 39814722
DOI: 10.1038/s41467-025-56128-x

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