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Article

A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.

Science (New York, N.Y.) - 15 Dec 2006

Taylor S, Barragan A, Su C, Fux B, Fentress S J, Tang K, Beatty W L, Hajj H El, Jerome M, Behnke M S, White M, Wootton J C, Sibley L D

Abstract excerpt

Toxoplasma gondii strains differ dramatically in virulence despite being genetically very similar. Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence of the type I lineage. Positional cloning identified the candidate virulence gene ROP18, a highly polymorphic serine-threonine kinase that was secreted into the host cell during...

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Identifiers

PMID: 17170305
DOI: 10.1126/science.1133643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.PMID 17170305Read ↗

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