Article
Diverse types of genetic variation converge on functional gene networks involved in schizophrenia.
Nature neuroscience - 1 Dec 2012
Gilman Sarah R, Chang Jonathan, Xu Bin, Bawa Tejdeep S, Gogos Joseph A, Karayiorgou Maria, Vitkup Dennis
Abstract excerpt
Despite the successful identification of several relevant genomic loci, the underlying molecular mechanisms of schizophrenia remain largely unclear. We developed a computational approach (NETBAG+) that allows an integrated analysis of diverse disease-related genetic data using a unified statistical framework. The application of this approach to schizophrenia-associated genetic variations, obtained using unbiased...
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