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Article

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses.

Neuron - 9 Jun 2011

Gilman Sarah R, Iossifov Ivan, Levy Dan, Ronemus Michael, Wigler Michael, Vitkup Dennis

Abstract excerpt

Identification of complex molecular networks underlying common human phenotypes is a major challenge of modern genetics. In this study, we develop a method for network-based analysis of genetic associations (NETBAG). We use NETBAG to identify a large biological network of genes affected by rare de novo CNVs in autism. The genes forming the network are primarily related to synapse development, axon targeting, and...

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Identifiers

PMID: 21658583
DOI: 10.1016/j.neuron.2011.05.021
PMCID: PMC3607702

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