Article
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.
Molecular psychiatry - 1 Sept 2012
Ayalew M, Le-Niculescu H, Levey D F, Jain N, Changala B, Patel S D, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger J I, Corvin A, Geyer M, Tsuang M T, Salomon D, Schork N J, Fanous A H, O'Donovan M C, Niculescu A B
Abstract excerpt
We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and gene expression studies in humans and animal models. Using this polyevidence scoring and pathway analyses, we identify top genes (DISC1, TCF4, MBP, MOBP, NCAM1, NRCAM, NDUFV2, RAB18, as well as...
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