Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip.

doi:10.1161/CIRCGENETICS.112.962852

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Article

Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip.

Circulation. Cardiovascular genetics - 1 Dec 2012

Gaunt Tom R, Shah Sonia, Nelson Christopher P, Drenos Fotios, Braund Peter S, Adeniran Ismail, Folkersen Lasse, Lawlor Debbie A, Casas Juan-Pablo, Amuzu Antoinette, Kivimaki Mika, Whittaker John, Eriksson Per, Zhang Henggui, Hancox Jules C, Tomaszewski Maciej, Burton Paul R, Tobin Martin D, Humphries Steve E, Talmud Philippa J, Macfarlane Peter W, Hingorani Aroon D, Samani Nilesh J, Kumari Meena, Day Ian N M

Abstract excerpt

BACKGROUND: Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death. METHODS AND RESULTS: In this study, 3 population-based cohorts (n=10,526) genotyped with the Illumina HumanCVD Beadchip and 4 quantitative electrocardiographic traits (PR interval, QRS axis, QRS duration, and QTc interval) were evaluated for single-nucleotide polymorphism...

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Identifiers

PMID: 23139254
DOI: 10.1161/CIRCGENETICS.112.962852

Genes

CAV1
CAV2
IGFBP3
KCNH2
KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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