Article
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.
Circulation - 2 Apr 2013
Ritchie Marylyn D, Denny Joshua C, Zuvich Rebecca L, Crawford Dana C, Schildcrout Jonathan S, Bastarache Lisa, Ramirez Andrea H, Mosley Jonathan D, Pulley Jill M, Basford Melissa A, Bradford Yuki, Rasmussen Luke V, Pathak Jyotishman, Chute Christopher G, Kullo Iftikhar J, McCarty Catherine A, Chisholm Rex L, Kho Abel N, Carlson Christopher S, Larson Eric B, Jarvik Gail P, Sotoodehnia Nona, Manolio Teri A, Li Rongling, Masys Daniel R, Haines Jonathan L, Roden Dan M
Abstract excerpt
BACKGROUND: ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias. METHODS AND RESULTS: We performed a genome-wide association study to identify genomic markers of QRS duration in 5272 individuals without cardiac disease selected from electronic medical record algorithms at 5 sites in the...
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