Article
Current Techniques for Complex Phenotypes: GWAS of the Electrocardiogram.
Trends in genetics : TIG - 1 Dec 2020
Fauman Eric B
Abstract excerpt
By sampling 500 time points of an electrocardiogram (ECG) trace in a genome-wide association study (GWAS), Verweig et al. identified novel correlates for cardiac dysfunction. Clustering of SNPs based on their impact at all time points revealed natural sets of SNPs with similar effects and mechanisms. Similar approaches may be applicable to other quantitative, time-ordered traits.
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