Article
Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions.
Retrovirology - 30 Jul 2016
Gasser Romain, Hamoudi Meriem, Pellicciotta Martina, Zhou Zhicheng, Visdeloup Clara, Colin Philippe, Braibant Martine, Lagane Bernard, Negroni Matteo
Abstract excerpt
BACKGROUND: Covariation is an essential process that leads to coevolution of parts of proteins and genomes. In organisms subject to strong selective pressure, coevolution is central to keep the balance between the opposite requirements of antigenic variation and retention of functionality. Being the viral component most exposed to the external environment, the HIV-1 glycoprotein gp120 constitutes the main target...
Topics
- Amides
- Antigenic Variation
- CD4 Antigens
- Evolution, Molecular
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Fusion Inhibitors
- HIV-1
- Humans
- Polymorphism, Genetic