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Article

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.

Retrovirology - 10 Oct 2017

Liu Donglai, Wang Chu, Hora Bhavna, Zuo Tao, Goonetilleke Nilu, Liu Michael K P, Berrong Mark, Ferrari Guido, McMichael Andrew J, Bhattacharya Tanmoy, Perelson Alan S, Gao Feng

Abstract excerpt

BACKGROUND: Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses result in fitness losses. RESULTS: Strongly selected mutations were identified by analyzing 5'-half HIV-1 genome (gag/pol)...

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Share to Antibodies, Neutralizing
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Culture Techniques

Share to Enzyme-Linked Immunospot Assay

Share to Epitopes, T-Lymphocyte

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Genetic Fitness

Share to Immune Evasion

Source

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Identifiers

PMID: 29017536
DOI: 10.1186/s12977-017-0371-4
PMCID: PMC5634943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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