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Article

Selection bias at the heterosexual HIV-1 transmission bottleneck

10 Jul 2014

Abstract excerpt

Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve...

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PMID: 25013080
DOI: 10.1126/science.1254031

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