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Article

Unusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1.

Journal of virology - 1 Oct 2000

Yuste E, López-Galíndez C, Domingo E

Abstract excerpt

Repeated bottleneck passages result in fitness losses of RNA viruses. In the case of human immunodeficiency virus type 1 (HIV-1), decreases in fitness after a limited number of plaque-to-plaque transfers in MT-4 cells were very drastic. Here we report an analysis of entire genomic nucleotide sequences of four HIV-1 clones derived from the same HIV-1 isolate and their low-fitness progeny following 7 to 15...

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Identifiers

PMID: 11000225
DOI: 10.1128/jvi.74.20.9546-9552.2000
PMCID: PMC112385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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