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Article

Extreme genetic fragility of the HIV-1 capsid.

PLoS pathogens - 1 Jan 2013

Rihn Suzannah J, Wilson Sam J, Loman Nick J, Alim Mudathir, Bakker Saskia E, Bhella David, Gifford Robert J, Rixon Frazer J, Bieniasz Paul D

Abstract excerpt

Genetic robustness, or fragility, is defined as the ability, or lack thereof, of a biological entity to maintain function in the face of mutations. Viruses that replicate via RNA intermediates exhibit high mutation rates, and robustness should be particularly advantageous to them. The capsid (CA) domain of the HIV-1 Gag protein is under strong pressure to conserve functional roles in viral assembly, maturation,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23818857
DOI: 10.1371/journal.ppat.1003461
PMCID: PMC3688543

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Source receipt: pubmed, retrieved 7 Sept 2026.

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