Article
Gating pore currents and the resting state of Nav1.4 voltage sensor domains.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012
Gosselin-Badaroudine Pascal, Delemotte Lucie, Moreau Adrien, Klein Michael L, Chahine Mohamed
Abstract excerpt
Mammalian voltage-gated sodium channels are composed of four homologous voltage sensor domains (VSDs; DI, DII, DIII, and DIV) in which their S4 segments contain a variable number of positively charged residues. We used single histidine (H) substitutions of these charged residues in the Na(v)1.4 channel to probe the positions of the S4 segments at hyperpolarized potentials. The substitutions led to the formation...
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