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Article

Recurrent targets of aberrant somatic hypermutation in lymphoma.

Oncotarget - 1 Nov 2012

Khodabakhshi Alireza Hadj, Morin Ryan D, Fejes Anthony P, Mungall Andrew J, Mungall Karen L, Bolger-Munro Madison, Johnson Nathalie A, Connors Joseph M, Gascoyne Randy D, Marra Marco A, Birol Inanc, Jones Steven J M

Abstract excerpt

Somatic hypermutation (SHM) in the variable region of immunoglobulin genes (IGV) naturally occurs in a narrow window of B cell development to provide high-affinity antibodies. However, SHM can also aberrantly target proto-oncogenes and cause genome instability. The role of aberrant SHM (aSHM) has been widely studied in various non-Hodgkin's lymphoma particularly in diffuse large B-cell lymphoma (DLBCL). Although,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma Diagnosis and Treatment

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 23131835
DOI: 10.18632/oncotarget.653
PMCID: PMC3717795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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